This session examines how clinical trials are evolving worldwide amid technological innovation and shifting regulatory expectations. Speakers will address challenges in cross-border studies, new decentralised and e-trial models[SF1.1], real-world evidence integration, data-driven methodologies, participant-centric trial designs, evolving ethical standards and the impact of AI. Attention will be given to international harmonisation efforts and jurisdiction-specific developments. The panel will highlight key legal and compliance implications for sponsors, investigators/involved HCPs and HCOs as a whole as well as patients and authorities. Participants will leave with a global perspective on where clinical research is headed and how to navigate its emerging risks.